WebNov 13, 2024 · Mature CD8+ T cells are known as cytotoxic T cells (Tc) for their role in recognizing infected, damaged, or cancerous somatic cells and triggering death pathways via cytotoxic proteins. Their activation is mediated by the receptors TCR, CD8, and CD28, generating mature cells that can be further grouped into distinct Tc subsets. WebThe Impact of KLF2 Modulation on the Transcriptional Program and Function of CD8 T Cells Gavin C. Preston 1, Carmen Feijoo-Carnero, Nick Schurch2, Victoria H. Cowling, Doreen A. Cantrell1* 1 Department of Cell Signalling & Immunology, College of Life Sciences, University of Dundee, Dundee, United Kingdom, 2 Data Analysis Group, Department of
Functional impairment of HIV-specific CD8+ T cells precedes …
WebTo date, both KLF2 and KLF13 have been shown to be involved in the regulation of development of T cells. Expression of KLF2 is downregulated following treatment of T cells with anti-CD36 but may also be upregulated during the early stages of T cell activation.7 KLF2 has been shown to maintain T cells in a quiescent state8 to WebJul 17, 2009 · In particular, CD8 T cells often expressed more CXCR3 than CD4 T cells, and the percentage of KLF2-deficient T cells expressing CXCR3 increased with age. In contrast, direct KLF2 targets—CD62L and S1P 1 —were consistently downregulated in KLF2-deficient T cells, independently of age (data not shown). brian baxter youtube
Combined High-Throughput Approaches Reveal the Signals Driven …
WebHere we found that the KLF2 transcription factor serves to restrain Tfh cell generation. Induced KLF2 deficiency in activated CD4 + T cells led to increased Tfh cell generation and B cell priming, whereas KLF2 overexpression prevented Tfh cell production. KLF2 promotes expression of the trafficking receptor S1PR1, and S1PR1 downregulation is ... WebJul 19, 1999 · CD4 and CD8 mature T cells were isolated by immunomagnetic bead purification from C57BL/6 lymph nodes. Lymphocytes were incubated with biotinylated mAbs against CD45R, CD11b, I-A b, and either CD8 or CD4, then with magnetic streptavidin-coated beads (Dynal). Cells bound to Abs and beads were removed by magnetic force. WebCytotoxic T cell immunity in response to chronic infections and tumours is maintained by a specialized population of CD8+T cells that exhibit hallmarks of both exhausted and memory cells and give rise to terminally differentiated exhausted effector cells that contribute to viral or tumour control. brian baxter sandusky ohio