Irf7 function
WebApr 14, 2011 · IRF7: activation, regulation, modification and function Introduction. Interferon regulatory factors (IRFs) are a family of transcription factors comprised of nine members... Activation of IRF7. Activation of IRF7 is prerequisite for its functions as a transcription … WebThe observed association might be attributable to its close proximity with interferon regulatory factor 7 ( IRF7 ), because the strong LD ( r2 = 0.94) between this disease-associated SNP and a 3′ UTR PHRF1 SNP (rs702966) is within 0.6-kb flanking region of the IRF7 gene (51). IRF7, similar to IRF5, is a transcription factor that can activate ...
Irf7 function
Did you know?
WebSystemic lupus erythematosus is an autoimmune disease attributing to a combination of genetic and environmental factors. Abnormal expression/function of type I interferons has been demonstrated with the pathogenesis of SLE, especially IFN-α, which can be regulated by IFN regulatory factor 7 (IRF7). WebJan 6, 2014 · Notably, IRF7 can function as a transcriptional activator or a repressor, depending on the cell type and its intrinsic transactivation potential. 19, 20 Accordingly, …
WebIn order to clarify the role of IRF7 in STAD, we further performed an enrichment analysis of IRF7 in STAD using the Function module of LinkedOmics. IRF7-associated gene analysis revealed that a total of 4978 genes (dark red dots) showed a positive correlation with IRF7 and 3659 genes (dark green dots) were negative correlation with IRF7 in STAD ... WebIRF7 is required for the production and amplification of the antiviral type I (IFN-α/β) and III (IFN-λ) IFNs. The patient's fibroblasts displayed impaired IFN-β and IFN-λ1 production in …
WebIn order to clarify the role of IRF7 in STAD, we further performed an enrichment analysis of IRF7 in STAD using the Function module of LinkedOmics. IRF7-associated gene analysis … WebAug 13, 2024 · Role of IRF7 in HSV-1-infection-induced interferon β (IFN-β) secretion by the corneal endothelial cells. ( a) The IRF7 gene DNA binding domain (DBD) of HCEn cells was disrupted by the...
WebJun 2, 2024 · Ciancanelli and colleagues reported on a 7-year-old girl with life-threatening ARDS from pandemic H1N1 2009 influenza A virus who was found to have compound heterozygous IRF7 variants leading to a loss of IRF7 function and impaired production of type I and III IFNs in response to influenza infection.
WebIn the present study, we used both gain-of-function and loss-of-function approaches to decipher the potential role of IRF7 in pathological cardiac hypertrophy. For the first time, we observed that overexpression of IRF7 in the heart limited chronic pressure overload–induced cardiac remodeling, whereas loss of IRF7 resulted in detrimental ... raymond simpson aberdeenWebApr 4, 2024 · IRF7 plays a role in reducing bone metastasis of prostate cancer by IFN-beta-mediated NK activity. The MYC is shown to be recruited to the IRF7 promoter region … raymond simon mdWebOct 10, 2014 · IRF7 is essential for inducing the expression of the type I IFN gene, 6, 12 the negative regulator of arterial intimal lesions in vivo and in vitro, 13, 14 which suggests that IRF7 potentially affects neointima formation. simplify 56:24WebDec 23, 2011 · In concordance with this, we show that levels of IRF7 are increased with EAE severity. Thus, the increased IRF7 expression may represent a protective function for IRF7 in EAE. The mechanism by which type I IFNs regulate CNS inflammation has been shown to include reduction of leukocyte migration to the CNS and inhibition of T cell responses [23 ... simplify 5 6-3 +2WebJul 7, 2024 · Thus, interferon-independent functions of STING mediate STING-dependent antiviral responses in vivo. Introduction The immune response to pathogens is initiated upon detection of... raymond simpson fbIRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including the type I interferon genes. In particular, IRF7 regulates many interferon-alpha genes. Constitutive expression of IRF7 is largely restricted to lymphoid tissue, largely plasmacytoid dendritic cells, whereas IRF7 is inducible in many tissues. Multiple IRF7 tra… simplify 56/30WebSep 6, 2024 · Previously, we found that IRF3 and IRF7 could mediate the acquisition of new anti-tumor effector functions in macrophages . In the present study, we observed that high IRF3 and IRF7 expression was related to CD4 + T cell, CD8 + T cell, B-cell, and macrophage activation, indicating that IRF3 and IRF7 could promote the anticancer effect of immune ... raymond singh