Cystatin domain
WebMar 18, 2011 · Tarocystatin (CeCPI) from taro (Colocasia esculenta cv. Kaohsiung no. 1), a group-2 phytocystatin, shares a conserved N-terminal cystatin domain (NtD) with other phytocystatins but contains a C-terminal cystatin-like extension (CtE). The structure of the tarocystatin–papain complex and the domain interaction between NtD and CtE in … WebJul 10, 2008 · This carboxy terminal extensions are recognized by the Pfam motif database as a cystatin domain, which suggest that C-extensions of plant cystatins are degenerated parts of a dimeric cystatin that probably originated by gene duplication followed by divergent evolution. Curiously, a stop codon is located between the two domains of …
Cystatin domain
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WebCystatins, the classical inhibitors of C1 cysteine proteinases, have been extensively studied and reviewed in the literature. Over the last 20 years, however, proteins containing … The cystatins are a family of cysteine protease inhibitors which share a sequence homology and a common tertiary structure of an alpha helix lying on top of an anti-parallel beta sheet. The family is subdivided as described below. Cystatins show similarity to fetuins, kininogens, histidine-rich glycoproteins and … See more The cystatin family includes: • The Type 1 cystatins, which are intracellular and are present in the cytosol of many cell types, but can also appear in body fluids at significant concentrations. They are single … See more Chicken cystatin quickly passed the membrane of MCF-10A neo T cells and inhibited cathepsin B when it was acylated with fatty acyl … See more • Cystatins at the U.S. National Library of Medicine Medical Subject Headings (MeSH) See more • Affimer, a type of engineered protein that is based on the cystatin scaffold See more • Cystatin: a protein that flips out! Interesting PDB structure article at PDBe • Lee C, Bongcam-Rudloff E, Sollner C, Jahnen-Dechent W, Claesson-Welsh L (January 2009). See more
WebJan 1, 2024 · The cystatins (CSTs) are secreted proteins 14- to 24-kDa in mass, which are distinguishable by a single cystatin domain, a typical signal peptide, and disulfide … WebConserved domains on [gi 156231021 ref NP_001095881 ] View ... Protein Classification. cystatin family protein (domain architecture ID 11249387) cystatin family protein similar to cystatins which are a family of cysteine protease inhibitors. Graphical summary. Zoom to residue level. show extra options » ...
WebMar 28, 2024 · cystatin domain containing 4. Synonyms. Gm5483 Feature Type. protein coding gene. IDs. MGI:3645124 NCBI Gene: 433016. Alliance. gene page. Transcription Start Sites. 1 TSS. Location & Maps more. Sequence Map Chr16:36004582-36008481 bp, + strand. From NCBI annotation of GRCm39 ... WebCystatin domain Provide feedback. Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. All members except Q03196 and Q10993 are found. PF00666 are related to this family but have not been included.
WebNov 18, 2009 · Subsequently, cystatins were divided into types 1, 2 and 3, based mainly on the number of cystatin domains . Recently, another system of classifying peptidase (protease) inhibitors was introduced, based on similarities in protein sequences and three-dimensional (3D) structures.
WebThis cystatin-like domain contains some of the elements known to be important for inhibitory activity. CTSF encodes a predicted protein of 484 amino acids which contains a 19 residue signal peptide. daniels family funeral services rio ranchoWebNov 18, 2009 · The cystatin superfamily consists of a large group of cystatin domain-containing proteins, most of which are reversible and tight-binding inhibitors of the papain (C1) and legumain (C13) families of cysteine proteases [1–4].On the basis of sequence similarity, the presence or lack of disulfide bonds, and physiological localization, this … daniels family potteryWebApr 1, 2001 · Human cystatin C, an amyloidogenic protein, dimerizes through three-dimensional domain swapping. The crystal structure of human cystatin C, a protein with … daniels family tartanWebThe cystatin superfamily (stefins, cystatins and kininogens) is the classical inhibitors of papain-like cysteine proteinases. Cystatin C is the most potent endogenous inhibitor of CTSS. Cystatin is constitutively expressed by most cells and contains a signal peptide enabling its secretion to the extracellular milieu [70]. daniels farm school.comWebMar 21, 2024 · CSTB (Cystatin B) is a Protein Coding gene. Diseases associated with CSTB include Myoclonic Epilepsy Of Unverricht And Lundborg and Unverricht-Lundborg … birth countdownWebJul 1, 2008 · Protein Cystatin domain-containing 4 Gene Cstdc4 Status UniProtKB unreviewed (TrEMBL) Organism Mus musculus (Mouse) Amino acids 97 Protein existence Evidence at protein level Annotation score 2/5 Entry Feature viewer Publications External links History BLAST Download Add a publication Entry feedback Function Features … birth counterWebSep 3, 2001 · Cystatins, an amyloid-forming structural superfamily, form highly stable, domain-swapped dimers at physiological protein concentrations. In chicken cystatin, the active monomer is a kinetic trap … daniels farm school membership toolkit